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C - Czynnik transkrypcyjny (pl)

Czynnik transkrypcyjny jest białkiem wiążącym DNA na obszarze promotora bądź sekwencji wzmacniającej w specyficznym miejscu lub regionie, gdzie reguluje proces transkrypcji. Czynniki transkrypcyjne mogą być selektywnie aktywowane, bądź dezaktywowane przez inne białka, najczęściej na ostatnim etapie przekazywania sygnału w komórce.

Klasy czynników transkrypcyjnych
Są trzy klasy czynników transkrypcyjnych:
• Ogólne czynniki transkrypcyjne zaangażowane w tworzenie kompleksu preinicjacyjnego
• Wiodące czynniki transkrypcyjne nieregulowane białka wiążęce się do nici wiodącej DNA przed miejscem inicjacji. Stymulują bądź inhibują proces transkrypcji
• Indukowalne czynniki transkrypcyjne podobne do wiodących czynników transkrypcyjnych ale wymagają aktywacji bądź inhibicji.
Motywy w czynnikach transkrypcyjnych
• Helisa-Skręt-Helisa (ang. Helix-Turn-Helix) wiąże się do głównego rowka DNA
• Palec cynkowy strukturalna płaszczyzna dla procesu wiązania DNA
• Domena zasadowa bogata w aminokwasy zasadowe, odpowiada za wiązanie się z DNA
• Zamek leucynowy wiąże między sobą czynniki transkrypcyjne
• Helisa-Pętla-Helisa (HLH, ang. Helix-Loop-Helix)odpowiada za dimeryzację

źródło: http://pl.wikipedia.org/wiki/Czynnik_transkrypcyjny


Data utworzenia: 19/02/2007 @ 19:06
Ostatnie zmiany: 19/02/2007 @ 19:06
Kategoria : C
Strona czytana 15562 razy


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